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KMID : 0043320190420060466
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Archives of Pharmacal Research
2019 Volume.42 No. 6 p.466 ~ p.480
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Bookmarking by histone methylation ensures chromosomal integrity during mitosis
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Kim Ja-Eun
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Abstract
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The cell cycle is an orchestrated process that replicates DNA and transmits genetic information to daughter cells. Cell cycle progression is governed by diverse histone modifications that control gene transcription in a timely fashion. Histone modifications also regulate cell cycle progression by marking specific chromatic regions. While many reviews have covered histone phosphorylation and acetylation as regulators of the cell cycle, little attention has been paid to the roles of histone methylation in the faithful progression of mitosis. Indeed, specific histone methylations occurring before, during, or after mitosis affect kinetochore assembly and chromosome condensation and segregation. In addition to timing, histone methylations specify the chromatin regions such as chromosome arms, pericentromere, and centromere. Therefore, spatiotemporal programming of histone methylations ensures epigenetic inheritance through mitosis. This review mainly discusses histone methylations and their relevance to mitotic progression.
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KEYWORD
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Histone modification, Histone methylation, Epigenetics, Cell cycle, Mitosis, Chromosomal stability
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